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Long noncoding RNA variations in cardiometabolic diseases

Sariya Dechamethakun1, Masaaki Muramatsu1

  • 1Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Journal of Human Genetics
|June 17, 2016
PubMed

Insights

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cardiometabolic diseases. Understanding lncRNA variations is crucial for defining gene regulation mechanisms in these complex conditions.

Area of Science:

  • Genetics
  • Molecular Biology
  • Cardiology

Background:

  • Cardiometabolic diseases involve multiple risk factors like diabetes, dyslipidemia, hypertension, and obesity, contributing to atherosclerosis and cardiovascular mortality.
  • Genome-wide association studies (GWASs) have identified genetic variants associated with cardiometabolic diseases, but these explain limited variability.
  • Susceptibility variants often lie in noncoding genomic regions, highlighting the importance of noncoding elements, including noncoding RNAs (ncRNAs).

Purpose of the Study:

  • To summarize recent discoveries concerning long noncoding RNA (lncRNA) variations in the context of cardiometabolic diseases.
  • To underscore the functional role of lncRNAs in cardiometabolic traits and human diseases.
  • To emphasize the need for better-defined molecular mechanisms of gene regulation by lncRNAs in cardiometabolic diseases.

Main Methods:

  • Review of recent scientific literature and genome-wide association studies (GWASs).
  • Analysis of emerging evidence on the functional roles of noncoding RNAs (ncRNAs), specifically microRNAs and long noncoding RNAs (lncRNAs).
  • Focus on genetic variations within noncoding genomic regions associated with cardiometabolic diseases.

Main Results:

  • Emerging evidence indicates that ncRNAs, including lncRNAs, play functional roles in the physiology and pathophysiology of human diseases.
  • lncRNAs are implicated in gene regulation through interactions with other molecules, influencing the development of various disorders.
  • Specific lncRNA variations are associated with cardiometabolic traits, though detailed regulatory mechanisms require further investigation.

Conclusions:

  • lncRNAs represent a significant area of research in understanding cardiometabolic diseases.
  • Further research into lncRNA variations and their molecular mechanisms is essential for advancing the field.
  • lncRNAs hold potential as therapeutic targets or biomarkers for cardiometabolic conditions.

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