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Cerebral ischemia in the developing primate fetus.

R E Myers1

  • 1Cincinnati VA Medical Center, Ohio.

Biomedica Biochimica Acta
|January 1, 1989
PubMed
Summary

Disrupting fetal blood flow to the brain early in gestation causes brain abnormalities in rhesus monkeys. Later disruptions had no effect, indicating a critical developmental window for brain injury.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Primate Research

Background:

  • Fetal brain development is highly sensitive to disruptions in blood supply.
  • Understanding the timing of vascular insults is crucial for predicting neurological outcomes.

Purpose of the Study:

  • To investigate the impact of induced cerebral ischemia at different gestational stages on fetal brain development in rhesus monkeys.
  • To determine the critical window for cerebral blood supply vulnerability during primate gestation.

Main Methods:

  • Bilateral ligation of common carotid arteries and jugular veins in rhesus monkey fetuses during the last two-thirds of gestation.
  • Pathological examination of surviving fetuses delivered at term.

Main Results:

  • Ligation before 82 days of gestation consistently resulted in brain abnormalities.
  • Ligation between 55-110 days caused focal tissue destruction (6/12) or abnormal brain development (3/12).
  • Early middle-gestation ligation led to cerebral dysgenesis; late middle-gestation ligation caused focal destruction resembling hydranencephaly.
  • Ligation after 110 days of gestation did not produce observable brain abnormalities.

Conclusions:

  • Cerebral blood flow is critical for normal brain development in late-gestation rhesus monkeys.
  • The developing primate brain exhibits significant vulnerability to ischemia during the middle third of gestation.
  • The timing of vascular insult dictates the type and severity of brain malformation or damage.

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