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New aspects in mechanisms of antihypoxic piracetam action
C Wustmann1, H D Fischer, E Rudolph
1Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, DDR.
Biomedica Biochimica Acta
|January 1, 1989
Abstract:
A long-term piracetam treatment leads to an improved stimulus-effect-coupling of potassium stimulated dopamine release: The maximum effect of the potassium stimulus is already obtained in presence of much lower Ca++-concentrations (Ca++-economizing effect) than normally. In consequence of the improved stimulus-effect-coupling by piracetam treatment the dose-dependent inhibitory effect of the calcium antagonist flunarizine on the fractional efflux rate of dopamine is decreased. The volume of vesicular structures is not involved in the piracetam effect.