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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
LUNG CANCER METASTASIS TO THE SPINE
Ahmet Levent Aydin1, Erhan Emel, Mehdi Sasani
1Koc University School of Medicine.
Background:
In patients affected by malignant tumors, spinal column metastases are frequent. Incidence varies between 30% -70%. Lung cancer is the second most frequent cancer invading spine in women, following breast cancer. In men, the first. All patients are under risk of symptomatic spinal cord compression. Prognosis is poor. Indications for surgery are progressive neurologic deficit, intractable pain, and impending vertebral fracture. Treatment is to preserve neurologic function, promote pain relief and provide functional improvement.
Study Design:
Report of five patients with symptomatic thoracic vertebral invasion secondary to lung cancer who underwent nine surgical procedures. In all patients, invasion to spinal column was from neighbouring lung tissue by direct extension or through segmental arteries.
Methods:
Five patients with symptomatic metastatic spinal cord compression at thoracal level, secondary to lung cancer were operated. They were evaluated regarding neurologic status, pain and disability scores, tumor type, level, surgical procedure.
Conclusion:
Lung cancer is an aggressive tumor. Patients with symptomatic spinal cord compression must be treated aggressively. With current spinal surgical techniques and with the coordinated effort, the life expectancy and quality of these patients are extended.
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