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Delayed progression of rabies transmitted by a vampire bat
Iana Suly Santos Katz1, Natalia Langenfeld Fuoco2, Luciana Botelho Chaves2
1Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil. ianasuly@gmail.com.
Archives of Virology
|June 17, 2016
Summary
Rabies virus (RABV) from vampire bats replicated faster but spread slower, causing later symptoms. Bat RABV variants exhibit distinct growth and disease patterns compared to canine and marmoset strains.
Area of Science:
- Virology
- Infectious Diseases
- Comparative Pathology
Background:
- Rabies virus (RABV) poses a significant global health threat.
- Understanding the diversity and behavior of RABV variants is crucial for disease control.
- Bat-borne rabies viruses are of particular concern due to their unique ecological niche.
Purpose of the Study:
- To compare the biological characteristics of RABV variants from vampire bats, dogs, and marmosets.
- To investigate differences in viral replication, cell-to-cell spread, and internalization kinetics.
- To correlate viral properties with observed clinical symptoms and mortality.
Main Methods:
- In vitro analysis of growth kinetics in N2a cells.
- Assessment of cell-to-cell spread and virus internalization.
- In vivo evaluation of clinical symptoms and mortality in animal models.
- Comparative analysis of viral variants V-3 (bat), V-2 (dog), and V-M (marmoset).
Main Results:
- The vampire bat RABV variant (V-3) exhibited significantly higher replication rates compared to V-2 and V-M.
- Viral uptake and cell-to-cell spread were inversely proportional to replication rates.
- V-3 displayed longer incubation and evolution periods.
- Bat RABV variant infections manifested clinically at a later stage than canine and marmoset variants.
Conclusions:
- Bat-borne RABV variants possess distinct biological properties influencing disease progression.
- Higher replication does not necessarily equate to faster disease onset.
- These findings highlight the importance of considering variant-specific characteristics in rabies epidemiology and management.