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sMICA as novel and early predictors for acute myocardial infarction
Cunyu Fu1, Yunxiang Shi2, Zongqin Yao1
1Department of Cardiovascular Medicine, Yishui Central Hospital, Linyi, Shandong, China.
Background And Aims:
MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form (sMICA). In the present study, we designed to investigate the serum sMICA level in patients with AMI and determine whether sMICA could be an early biomarker for diagnosis of AMI.
Methods:
There were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.
Results:
Serum levels of sMICA reach the peaks [(1.34 ± .18 and 1.72 ± .20)n/l] at 6-12 h and serum levels of cTnT reach the peaks [(1.16 ± .28 and 1.14 ± .34)n/l] at 12-24 h. Both of them were significantly higher than the healthy controls [(.168 ± .014) n/l, p = .000] for sMICA and [(.13 ± .06) n/l, p = .000] for Troponin T (cTnT). sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 (95 % CI .69-.83) in discriminating AMI patients from healthy controls.
Conclusions:
We have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans.
Insights
Soluble MHC class I polypeptide-related chain A (sMICA) shows elevated levels in patients with acute myocardial infarction (AMI). This suggests sMICA may serve as a novel early biomarker for detecting myocardial injury.
Area of Science:
- Immunology
- Cardiology
- Biomarker Discovery
Background:
- MHC class I polypeptide-related chain A (MICA) is induced by stress and infection.
- MICA sheds into soluble form (sMICA) in the extracellular domain.
- sMICA elevation is observed in conditions like ischemia and reperfusion.
Purpose of the Study:
- Investigate serum sMICA levels in patients with acute myocardial infarction (AMI).
- Determine if sMICA can serve as an early diagnostic biomarker for AMI.
Main Methods:
- Studied 103 patients with first-time AMI and 103 healthy controls.
- Measured serum sMICA and Troponin T levels using ELISA kits.
- Analyzed sMICA and Troponin T peak levels and compared them to controls.
Main Results:
- Serum sMICA peaked at 6-12 hours, while Troponin T peaked at 12-24 hours.
- Both sMICA and Troponin T levels were significantly higher in AMI patients than in controls (p < 0.000).
- sMICA demonstrated higher sensitivity for early AMI diagnosis compared to Troponin T, with an AUC of 0.78.
Conclusions:
- Elevated serum sMICA levels were detected in patients with AMI.
- sMICA shows potential as a novel biomarker for early myocardial injury detection in humans.
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