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Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment

Jie Sun, Wenqing Xia, Rongrong Cai

  • 1Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, No.87 Ding-JiaQiao Road, Nanjing, PR China, 210009. gyjwsh@163.com.

Current Alzheimer Research
|June 17, 2016
PubMed
Abstract

Insights

In type 2 diabetes patients, higher insulin degrading enzyme (IDE) levels were linked to better cognitive function in mild cognitive impairment (MCI). Lower IDE levels were associated with an increased likelihood of MCI.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Endocrinology

Background:

  • Insulin degrading enzyme (IDE) plays a role in degrading insulin and amyloid-beta (Aβ).
  • Type 2 diabetes is associated with an increased risk of cognitive impairment.
  • The specific role of IDE in type 2 diabetes patients with mild cognitive impairment (MCI) requires further investigation.

Purpose of the Study:

  • To investigate the association between serum IDE levels and mild cognitive impairment (MCI) in patients with type 2 diabetes.
  • To explore the relationship between IDE, cognitive function, and glycemic control in this population.

Main Methods:

  • 146 individuals with type 2 diabetes were enrolled and categorized into MCI and non-MCI groups based on Montreal Cognitive Assessment (MoCA) scores.
  • Serum IDE levels, demographic characteristics, and cognitive function were assessed.
  • Correlation and logistic regression analyses were performed to determine the relationship between IDE and MCI.

Main Results:

  • Diabetic patients with MCI exhibited significantly higher serum IDE levels compared to those without MCI.
  • Serum IDE levels were positively correlated with MoCA scores and negatively correlated with Trail Making Test-B, fasting blood-glucose, HbA1c, HOMA-IR, and MAGE.
  • IDE was identified as an independent variable associated with MCI in logistic regression analysis, even after adjusting for confounding factors.

Conclusions:

  • This study suggests that higher serum IDE levels are associated with a lower likelihood of MCI in type 2 diabetes patients.
  • IDE may serve as a potential biomarker for cognitive impairment in individuals with type 2 diabetes.

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