Related Experiment Video
Updated: Mar 19, 2026
09:45
Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
7.4K
Changes in neurosyphilis presentation: a survey on 286 patients
F Drago1, G Merlo2, G Ciccarese1
1Di.S.Sal. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
Summary
Neurosyphilis (NS) is increasing globally, presenting with diverse and atypical symptoms. Many recent studies lack crucial clinical and treatment details, hindering effective analysis of penicillin
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Neurosyphilis (NS) remains a global health concern, frequently presenting with subtle or atypical symptoms.
- Recent literature often lacks detailed clinical histories and prior treatment information, complicating NS understanding.
- The prevalence of neurosyphilis appears to be rising worldwide.
Purpose of the Study:
- To analyze the clinical presentation of neurosyphilis over the past five years.
- To identify common manifestations and document reporting deficiencies in recent NS literature.
Main Methods:
- A literature survey of articles published in the last five years concerning neurosyphilis.
- Analysis of 137 articles reporting on 286 neurosyphilis patients.
- Recording of clinical manifestations and assessment of information completeness.
Main Results:
- General paresis was the most frequent form (49%), characterized by cognitive and psychiatric symptoms.
- Syphilitic meningitis occurred in 22% of cases, often with ocular or auditory deficits.
- Meningovascular and tabetic forms each represented 12% of cases; gummatous and epileptic forms were rare.
Conclusions:
- Neurosyphilis prevalence is increasing, with a tendency towards atypical and delayed presentations.
- A significant number of published studies lack essential clinical and therapeutic data.
- Incomplete reporting hinders the assessment of penicillin's efficacy in preventing neurosyphilis.
More Related Videos
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
709
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
709
01:25Arboviral Encephalitis
1
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
1
01:26Sexually Transmitted Infections
1.5K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.5K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
605
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
605
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
488
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
488
01:30Coronary Artery Disease III: Clinical Manifestations
526
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
526