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Related Experiment Video

Updated: Mar 19, 2026

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Neuromyelitis optica and pregnancy.

Ameneh Zare-Shahabadi1,2, Hamidreza Ghalyanchi Langroodi1, Amir Reza Azimi1

  • 1Department of Neurology, MS Research Center, Neuroscience Institute, Sina Hospital, Tehran University of Medical Science, Imam Khomeini Ave., Hasan Abad Sq., Tehran, Iran.

Acta Neurologica Belgica
|June 17, 2016
PubMed
Summary

Neuromyelitis optica (NMO) and NMO spectrum disorders impact women of childbearing age. This review examines NMO in pregnancy and treatment safety for these demyelinating conditions.

Keywords:
NMONeuromyelitis opticaPregnancy

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Area of Science:

  • Neurology
  • Immunology
  • Reproductive Medicine

Background:

  • Neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) are autoimmune demyelinating diseases.
  • These conditions primarily affect the optic nerves and spinal cord.
  • NMO/NMOSD exhibit a significant female predominance, with many patients in their reproductive years.

Purpose of the Study:

  • To review current literature on Neuromyelitis optica and pregnancy.
  • To discuss the impact of pregnancy on the disease course of NMO/NMOSD.
  • To evaluate the safety of available therapeutic options during pregnancy for NMO/NMOSD patients.

Main Methods:

  • Literature review of recent studies.
  • Focus on disease course during pregnancy.
  • Analysis of treatment safety data in pregnant NMO/NMOSD patients.

Main Results:

  • Pregnancy significantly influences the clinical course of NMO/NMOSD.
  • Specific treatment options demonstrate varying safety profiles during gestation.
  • Evidence-based recommendations for managing NMO/NMOSD in pregnancy are emerging.

Conclusions:

  • Management of NMO/NMOSD during pregnancy requires careful consideration of disease activity and treatment risks.
  • Further research is needed to optimize therapeutic strategies for pregnant individuals with NMO/NMOSD.
  • Multidisciplinary care involving neurologists and obstetricians is crucial for optimal outcomes.