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Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in
K A Mitropoulos1, G J Miller, B E Reeves
1MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, U.K.
Insights
This study found that large lipoprotein particles, like chylomicrons, are key determinants of factor VII coagulant activity (VIIc) in middle-aged men. These findings link lipoprotein levels to blood clotting factors in the general community.
Area of Science:
- Biochemistry
- Hematology
- Lipid Metabolism
Background:
- Factor VII coagulant activity (VIIc) is a risk factor for cardiovascular disease.
- Previous studies have shown associations between VIIc and plasma lipid concentrations.
Purpose of the Study:
- To investigate the determinants of VIIc in a general community sample.
- To explore the relationship between VIIc and lipoprotein profiles.
Main Methods:
- Community-based survey of middle-aged men in NW London.
- Analysis of non-fasting plasma samples for VIIc and lipoprotein profiles.
- Statistical analysis to identify associations between VIIc and various lipoprotein fractions.
Main Results:
- VIIc is strongly and positively associated with large lipoprotein particles: chylomicrons, VLDL, and IDL.
- A significant negative association was observed between VIIc and the ratio of lipid in the d > 1.019 fraction to total plasma lipid.
- Associations with smaller lipoproteins may be due to inter-fractional relationships, but chylomicron associations remain strong.
Conclusions:
- The concentration of large lipoprotein particles, particularly chylomicrons, significantly influences in vivo factor VII reactivity.
- Understanding these associations may provide insights into cardiovascular disease risk stratification.
Abstract:
A community survey of factor VII coagulant activity (VIIc) and the lipoprotein profile in non-fasting plasma of middle-aged men in NW London was undertaken to search for the determinants of VIIc in the general community. The data demonstrates that associations between VIIc and the plasma concentrations of cholesterol and of triglycerides previously shown in the general population can be explained by the strong and positive associations between VIIc and the large lipoprotein particles, chylomicrons, VLDL and IDL. Consistent with the possibility that the concentration of large lipoproteins determines the in vivo reactivity of factor VII, the association between VIIc and the ratio of lipid in the d greater than 1.019 fraction to the total plasma lipid was also highly significant but negative. The observed correlations between VIIc and lipoproteins smaller than VLDL may be the product of the interrelations that exist between the lipoprotein fractions in plasma. However, the associations between VIIc and the chylomicron lipid concentrations are especially strong when allowance is made for the considerable bias towards zero in the observed correlation, due to large within-person variance in chylomicron concentration.