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Cutaneous Collision Tumor Associated With Porocarcinomatous and Angiosarcomatous Components: A Potential Diagnostic
Rafael Parra-Medina1, Mario A Melo-Uribe, Oscar Messa-Botero
1*Department of Pathology, National Institute of Cancer, Bogotá, Colombia; †Department of Pathology, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; and ‡Department of Pathology, Universidad de La Sabana, Chia, Colombia.
Abstract:
Sarcomatoid eccrine porocarcinoma (SEP) is a very rare malignancy including epithelial and mesenchymal components exhibiting pleomorphic cells, nuclear hyperchromasia, and high mitotic activity in both elements. To date, only 6 cases of this uncommon neoplasm have been reported, corresponding to women over 70 years of age with ulcerated skin lesions. The authors describe the first sarcomatoid eccrine porocarcinoma in a 75-year-old male patient with a right hallux lesion, presenting a collision tumor with a mixed population of epithelial cells and a spindle cell angiosarcomatous mesenchymal component each expressing distinct and nonoverlapping morphologic and immunohistochemical features of epithelial and mesenchymal differentiation.
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