Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent neonatal herpes presenting initially with hoarseness.

J C Opitz1, M A Kettrick, B J Sullivan

  • 1Department of Pediatrics, Marshfield Clinic, Wisconsin 54449.

American Journal of Perinatology
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.

Scientific reports·2018
Same author

Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years.

Lancet (London, England)·2009
Same author

A community intervention trial to promote judicious antibiotic use and reduce penicillin-resistant Streptococcus pneumoniae carriage in children.

Pediatrics·2001
Same author

Cecocutaneous fistula after remote appendectomy: case report.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·2000
Same author

Structural and functional characterization of an epitope in the conserved C-terminal region of HIV-1 gp120.

The journal of peptide research : official journal of the American Peptide Society·1999
Same author

Profound hypothermia and circulatory arrest with skull base approaches for treatment of complex posterior circulation aneurysms.

Acta neurochirurgica·1999

A newborn experienced recurrent herpes simplex meningoencephalitis, a severe brain infection, despite antiviral treatment. This case highlights potential immune system deficiencies in infants facing persistent viral infections.

Area of Science:

  • Neonatal Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Herpes simplex virus (HSV) infections can cause severe neurological complications in newborns.
  • Meningoencephalitis, an inflammation of the brain and its surrounding membranes, poses significant risks to infant health.
  • Antiviral therapies like acyclovir are standard treatments for HSV infections.

Observation:

  • A newborn presented with recurrent herpes simplex meningoencephalitis, an unusual clinical course.
  • The initial symptom was hoarseness, deviating from typical presentations.
  • Despite achieving adequate acyclovir levels in cerebrospinal fluid, a second episode or progression of encephalitis occurred.

Findings:

  • Recurrent meningoencephalitis suggests potential underlying impairments in host defenses, particularly cellular immunity.

Related Experiment Videos

  • Combined antiviral treatment with acyclovir and vidarabine was administered during the second episode.
  • Pharmacokinetic analysis of antiviral therapy and evaluation of immune responses are crucial.

    • Implications:

    • This case underscores the need to investigate immune function in neonates with severe or recurrent HSV infections.
    • Understanding host defense mechanisms is critical for managing challenging pediatric neurological conditions.
    • Further research into combined antiviral strategies and immune modulation may be warranted for refractory cases.