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Updated: Mar 19, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes
Saverio Marchi1, Carlotta Giorgi1, Monika Oparka2
1Department of Morphology; Surgery and Experimental Medicine ; Section of Pathology; Oncology and Experimental Biology and LTTA Center ; University of Ferrara ; Ferrara, Italy.
Abstract:
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum-mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.
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