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Updated: Mar 19, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Key regulators of apoptosis execution as biomarker candidates in melanoma

Emilie M Charles1, Markus Rehm1

  • 1Department of Physiology & Medical Physics; Royal College of Physics; Royal College of Surgeons in Ireland; Dublin 2, Ireland; Centre for Systems Medicine; Royal College of Surgeons in Ireland; Dublin 2, Ireland.

Molecular & Cellular Oncology
|June 17, 2016
PubMed

Insights

Malignant melanoma often resists apoptosis, impacting treatment efficacy. This study reviews apoptosis regulators as biomarkers for predicting melanoma patient outcomes and treatment response.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Malignant melanoma exhibits high resistance to apoptosis, complicating treatment.
  • Apoptosis resistance correlates with poor response to chemotherapy, radiotherapy, and novel therapies.
  • Key regulators of apoptosis are pro- and anti-apoptotic proteins.

Purpose of the Study:

  • To provide a comprehensive overview of biomarker discovery studies for apoptosis regulators in melanoma.
  • To critically review findings on apoptosis regulators as biomarkers.
  • To outline strategies for overcoming challenges in using these biomarkers.

Main Methods:

  • Literature review of biomarker discovery studies.
  • Critical analysis of research findings on apoptosis regulators.
  • Identification of current limitations and future strategies.

Main Results:

  • Numerous studies have investigated apoptosis-related proteins as potential biomarkers.
  • The interplay of pro- and anti-apoptotic proteins is central to apoptosis execution.
  • Challenges exist in translating biomarker findings into clinical practice.

Conclusions:

  • Apoptosis regulators hold promise as prognostic and predictive biomarkers in melanoma.
  • Further research is needed to overcome limitations in biomarker exploitation.
  • Developing effective biomarkers can improve melanoma patient management and treatment selection.
Keywords:
APAF-1IAP antagonistXIAPapoptosisbiomarkercaspasesmelanoma

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