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Targeting the sumoylation pathway in cancer stem cells

Maria V Bogachek1, James P De Andrade1, Ronald J Weigel2

  • 1Department of Surgery; University of Iowa ; Iowa City, IA USA.

Molecular & Cellular Oncology
|June 17, 2016
PubMed
Summary

Inhibition of the sumoylation pathway effectively eliminates cancer stem cells (CSCs) and reduces tumor growth in basal breast cancer models. This pathway presents a promising new therapeutic target for this cancer type.

Keywords:
CD44SUMOTFAP2Abasal breast cancercancer stem cellsepithelial-mesenchymal transitionsumoylation

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