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Updated: Mar 19, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
Porcine cancer models for translational oncology
Jessica C Sieren1, Dawn Quelle2, David K Meyerholz3
1Radiology and Biomedical Engineering; University of Iowa; Iowa City, IA USA; Holden Comprehensive Cancer Center; University of Iowa; Iowa City, IA USA.
Abstract:
Large-animal cancer models are needed to advance the development of innovative and clinically applicable tumor diagnostic, therapeutic, and monitoring technologies. We developed a genetically modified porcine model of cancer based on a TP53 mutation, and established its utility for tracking tumorigenesis in vivo through non-invasive clinical imaging approaches.
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