Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
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Updated: Mar 19, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Evelyne Ségal-Bendirdjian1, Mario P Tschan2, Josy Reiffers3
1INSERM UMR-S 1007; Cellular Homeostasis and Cancer; Université Paris Descartes; Sorbonne Paris Cite ; Paris, France.
Abstract:
p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells.
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