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Analysis of intratumor heterogeneity unravels lung cancer evolution
Elza C de Bruin1, Nicholas McGranahan2, Charles Swanton3
1Cancer Institute; UK by Cancer Institute ; London, UK.
Molecular & Cellular Oncology
|June 17, 2016
Abstract:
Lung cancer is a disease with dismal outcome. We recently reported a detailed intratumor heterogeneity analysis in 7 non-small cell lung cancer samples, revealing spatially separated driver events as well as the temporal dynamics of mutational processes and demonstrating an important role for APOBEC-mediated heterogeneity later in disease evolution.

