Related Experiment Video
Updated: Mar 19, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
Published on: March 9, 2012
GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling
Heide Marika Genau1, Christian Behrends1
1Institute of Biochemistry II, Goethe University School of Medicine ; Frankfurt am Main, Germany.
Abstract:
Spatially restricted signaling is a hallmark of RAC1 signaling. Recent work has uncovered a novel role of gamma-aminobutyric acid receptor-associated proteins (GABARAPs), a subfamily of human ATG8 ubiquitin-like modifiers, in providing a scaffold for recruitment of an ubiquitin E3 ligase complex to its substrate, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1), to enable ubiquitylation and thereby local control of RAC1 activity.
Related Concept Videos
Intracellular Signaling Affects Focal Adhesions
Some...
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Mechanism of Lamellipodia Formation
Rab Cascades
Microtubule Associated Proteins (MAPs)

