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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
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High hyperdiploid childhood acute lymphoblastic leukemia: Chromosomal gains as the main driver event
1Division of Clinical Genetics, Lund University , Lund, Sweden.
Molecular & Cellular Oncology
|June 17, 2016
Abstract:
High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.
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