Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Framing Effects03:26

Framing Effects

8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K
Impact of Social Context on Individuals01:21

Impact of Social Context on Individuals

425
Social psychology examines how the real or imagined presence of others influences individuals' thoughts, feelings, and behaviors. A key concept in this field is the role of social context in shaping behavior. The same individual may act differently depending on the social setting, due to the varying expectations and norms associated with each environment. This context-dependent behavior illustrates the influence of social roles, which prescribe appropriate conduct in specific situations.Social...
425
Chunking01:12

Chunking

507
Chunking is a powerful cognitive technique that improves short-term memory retention by organizing information into smaller, more manageable units. The brain, limited by working memory capacity, can more easily process and store information when it is divided into "chunks" rather than presented as discrete, unrelated elements. Chunking is especially useful when dealing with large amounts of information, such as numerical sequences, words, or complex ideas.
The principle behind chunking...
507
Timing and Consequences on Behavior01:08

Timing and Consequences on Behavior

598
In operant conditioning, the timing of reinforcement is crucial. For animals like rats and cats, immediate reinforcement (within a few seconds) is much more effective than delayed reinforcement. For example, a food reward for a rat needs to follow within 30 seconds of pressing a bar to be effective. 
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
598
Buffer Effectiveness02:19

Buffer Effectiveness

57.8K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
57.8K
Chunking and Rehearsal in Sensory Memory01:22

Chunking and Rehearsal in Sensory Memory

707
Improving short-term memory can be achieved through techniques like chunking and rehearsal. Chunking involves organizing information into larger, more manageable units. This technique is particularly useful for information that exceeds the typical memory span of between five and nine items. For instance, logging into an online account with a password like "ta89vq0179gz" involves grouping letters and numbers into three chunks—ta89, vq01, and 79gz. It makes large amounts of...
707

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SPL84 and trikafta® exhibit comparable and additive effects in patient-derived HBE cells carrying the 3849+10kb C→T/F508del CFTR variants.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Intestinal organoids as a platform for functional evaluation of ASO-mediated splicing modulation in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

The response of rare CFTR mutations to specific modulator combinations.

ERJ open research·2025
Same author

Insights into common fragile site instability: DNA replication challenges at DNA repeat sequences.

Emerging topics in life sciences·2023
Same author

Delivery Characterization of SPL84 Inhaled Antisense Oligonucleotide Drug for 3849 + 10 kb C- > T Cystic Fibrosis Patients.

Nucleic acid therapeutics·2023
Same author

Clinical and functional efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis carrying the N1303K mutation.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2023

Related Experiment Video

Updated: Mar 19, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

5.8K

To break or not to break - context matters.

Karin Miron1, Batsheva Kerem1

  • 1Department of Genetics, The Life Sciences Institute, The Hebrew University , Jerusalem, Israel.

Molecular & Cellular Oncology
|June 17, 2016
PubMed
Summary

Oncogene expression causes replication stress and genome instability. Our study reveals that oncogene-induced fragile sites are dynamic, adding complexity to cancer fragility.

Keywords:
Cancer breakagefragile sitesgenome instabilityoncogene expressionrecurrent fragilityreplication stress

More Related Videos

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects
07:36

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects

Published on: November 30, 2018

16.5K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.1K

Related Experiment Videos

Last Updated: Mar 19, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

5.8K
Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects
07:36

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects

Published on: November 30, 2018

16.5K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.1K

Area of Science:

  • Genetics
  • Cancer Biology
  • Genomics

Background:

  • Oncogene activation is a known driver of cellular dysfunction.
  • Replication stress and genome instability are hallmarks of cancer.
  • Fragile sites (FSs) are specific genomic regions prone to breakage.

Purpose of the Study:

  • To investigate the dynamic nature of oncogene-induced fragile sites.
  • To understand the complexity of recurrent genomic fragility in cancer.

Main Methods:

  • Utilizing genomic analysis techniques.
  • Employing cell-based models of oncogene expression.

Main Results:

  • Identified specific oncogene-induced fragile sites.
  • Demonstrated that the pattern of recurrent fragility is dynamic within the same cell type.
  • Uncovered a new layer of complexity in the molecular mechanisms underlying genomic instability.

Conclusions:

  • The landscape of oncogene-induced fragile sites is not static.
  • This dynamic nature has significant implications for understanding cancer development and progression.
  • Further research is needed to elucidate the precise molecular mechanisms driving this dynamic fragility.