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Updated: Mar 19, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
Published on: June 20, 2015
More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells
Christopher Heeschen1, Patricia Sancho1
1Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London , UK.
Abstract:
Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified a subset of CSCs with reduced mitochondrial content that showed resistance to mitochondrial targeting, but could be sensitized by inhibition of MYC.
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