Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles

Area of Science:

• * Mathematical modeling of transport phenomena.
• * Biophysics and pharmaceutical sciences.

Background:

• * Drug release kinetics from microparticles often involve complex diffusion and surface interactions.
• * Traditional diffusion models may not capture anomalous diffusion or non-Debye surface relaxation processes.

Purpose of the Study:

• * To introduce a generalized model for diffusion coupled with surface kinetics.
• * To investigate scenarios including anomalous diffusion and non-Debye surface relaxation.
• * To apply the model to experimental drug release data.

Main Methods:

• * Development of a general model based on fractional diffusion equations.
• * Coupling the diffusion equation with a kinetic equation via boundary conditions.
• * Application and validation of the model using experimental data of capsaicinoids release from Poly (ε-caprolactone) microparticles.

Main Results:

• * The model successfully describes various diffusion scenarios, including anomalous diffusion and surface relaxation.
• * The model shows good agreement with experimental data for capsaicinoids release.
• * A correlation between the initial burst drug release and anomalous diffusion is proposed.

Conclusions:

• * The proposed fractional diffusion-kinetic model provides a robust framework for analyzing complex drug release systems.
• * Anomalous diffusion is a potential mechanism underlying the burst release effect observed in Poly (ε-caprolactone) microparticles.
• * The model's ability to capture non-Debye surface relaxation broadens its applicability to diverse material-drug interactions.