Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

Biodiversity and Human Values

Biodiversity and Human Values

Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.

bioRxiv : the preprint server for biology·2026

Same author

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling.

Cell reports·2026

Same author

Biomolecular condensates mediate C-N bond formation.

Nature chemical biology·2026

Same author

Origins of the Intrinsic Redox Activity of Biomolecular Condensates.

Journal of the American Chemical Society·2026

Same author

Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization.

Nature chemistry·2026

Same author

Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins.

Journal of the American Chemical Society·2025

Search research articles

Related Experiment Video

Updated: Mar 19, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Priority of discovery in the life sciences.

Ronald D Vale¹, Anthony A Hyman²

¹Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.

|June 17, 2016

Summary

Scientists can improve how they claim priority for discoveries by separating disclosure through preprints from validation via peer review and community evaluation. This enhances scientific communication and credit attribution.

Keywords:

peer review post-publication peer review preprints priority scientific publishing

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Related Experiment Videos

Last Updated: Mar 19, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Area of Science:

Scientific communication
Research integrity
Scholarly publishing

Background:

Establishing priority of discovery is crucial for scientific careers and the reward system.
Current practices in biology often combine disclosure and initial validation within journal publications.
Principles for establishing priority are seldom explicitly discussed.

Purpose of the Study:

To analyze the fundamental components of establishing priority of discovery.
To propose a separation of disclosure and validation processes in scientific communication.
To discuss the benefits of using preprints for disclosure and multi-faceted approaches for validation.

Main Methods:

Conceptual analysis of scientific discovery and communication processes.
Examination of current publication and validation workflows in biological sciences.
Proposal of a revised model integrating preprints and diverse validation mechanisms.

Main Results:

Priority of discovery can be broken down into distinct steps: disclosure and validation.
Current journal publication practices merge these two essential steps.
Separating disclosure (via preprints) and validation (via peer review and community assessment) offers advantages.

Conclusions:

A revised model separating disclosure and validation can improve the attribution of scientific credit.
Preprints serve as an effective mechanism for rapid disclosure of scientific findings.
A combination of formal peer review and broader community evaluation enhances validation and scientific rigor.