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Related Experiment Video

Updated: Mar 19, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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[Rheumatoid arthritis and malignancy].

Tomohiro Kameda, Hiroaki Dobashi

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |June 18, 2016
    PubMed
    Summary

    Rheumatoid arthritis (RA) patients face higher mortality, with cancer being a key factor. Higher doses of methotrexate (MTX) increase the risk of developing MTX-associated lymphoproliferative disorder (MTX-LPD) in these patients.

    Area of Science:

    • Rheumatology
    • Oncology
    • Immunology

    Context:

    • Rheumatoid arthritis (RA) is linked to increased mortality, particularly from malignancies.
    • While overall cancer incidence in RA is comparable to the general population, specific cancers like malignant lymphoma and lung cancer show increased risk.
    • Certain conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are potential risk factors for malignancy in RA patients.

    Purpose:

    • To investigate the risk factors for malignancy in rheumatoid arthritis (RA) patients.
    • To specifically examine the association between methotrexate (MTX) treatment and lymphoproliferative disorders (LPD) in RA.
    • To identify if MTX dosage is an independent risk factor for MTX-associated lymphoproliferative disorder (MTX-LPD) in Japanese RA patients.

    Summary:

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    • This study identified that the mean dose of methotrexate (MTX) is an independent risk factor for the onset of MTX-associated lymphoproliferative disorder (MTX-LPD) in rheumatoid arthritis (RA) patients.
    • Data suggests that higher MTX doses are associated with an increased risk of LPD development in Japanese RA patients.
    • Malignancy, including MTX-LPD, is a significant cause of excess mortality in RA patients.

    Impact:

    • Findings highlight the importance of MTX dosage in managing RA treatment to mitigate the risk of LPD.
    • This research contributes to a better understanding of cancer risks in RA patients, particularly concerning specific drug therapies.
    • The study provides crucial data for oncologists and rheumatologists in optimizing RA treatment strategies and patient monitoring for malignancy risk.