Related Experiment Video
Updated: Mar 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Bisphosphonate related osteonecrosis of calvarial bone
James Prueter1, Ambujakshan Dildeep2
1Grandview Medical Center, 405 West Grand Ave, Dayton, OH.
Background:
A case of bisphosphonate related osteonecrosis of calvarial bone has not been reported.
Methods:
The clinical, imaging, and histopathological findings of the patient are presented. A 72-year-old female treated with bisphosphonates for osteoporosis presented with an open wound of her scalp. CT, MRI and bone scan suggested lytic and sclerotic changes with inflammation.
Results:
Surgical debridement was performed and final pathology was consistent with osteonecrosis and osteomyelitis.
Conclusions:
This case illustrates that bisphosphonates can induce osteonecrosis of calvarial bone.
Related Concept Videos
Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Osteoclasts in Bone Remodeling
What is the Skeletal System?
Skeleton and Calcium Homeostasis

