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Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22
A P Palumbo1, M Boccadoro, S Battaglio
1Dipartimento di Medicina e Oncologia Sperimentale, Universita' di Torino, Italy.
Cancer Genetics and Cytogenetics
|May 1, 1989
Abstract:
We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).