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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Toolbox for Antibiotics Discovery from Microorganisms.

Katja M Fisch1, Till F Schäberle2

  • 1Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany.

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|June 18, 2016
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Summary
This summary is machine-generated.

Microorganisms yield natural products for drug discovery. This review covers methods from strain isolation and genomic mining to heterologous expression for producing potential pharmaceutical leads.

Keywords:
AntibioticsDrug discoveryGenome miningNRPSPKS

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Area of Science:

  • Microbiology
  • Natural Product Chemistry
  • Medicinal Chemistry

Background:

  • Microorganisms synthesize diverse biologically active metabolites.
  • Natural products are crucial sources for drug leads in pharmaceutical research.
  • Identifying and producing these compounds is vital for medicinal chemistry.

Purpose of the Study:

  • To review tools for discovering and producing natural product drug leads.
  • To provide an overview of the workflow from strain isolation to heterologous expression.
  • To highlight methods for identifying and generating potential therapeutic compounds.

Main Methods:

  • Isolation of novel microbial producer strains.
  • Genomic and metagenomic mining to identify natural product biosynthetic gene clusters.
  • Heterologous expression systems for producing target compounds.

Main Results:

  • Detailed explanation of current tools and techniques.
  • Comprehensive overview of the discovery and production pipeline.
  • Demonstration of feasibility for producing potential drug leads.

Conclusions:

  • The discussed tools facilitate the discovery of novel drug leads from microbial sources.
  • Genomic mining and heterologous expression are powerful strategies for natural product drug development.
  • This integrated approach accelerates the path from microbial metabolite to pharmaceutical application.