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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: protocol for a
Fernando Pires Hartwig1, Neil Martin Davies2, Bernardo Lessa Horta1
1Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
BMJ Open
|June 18, 2016
Summary
This study investigates the gene-breastfeeding interaction involving FADS2 variants and intelligence (IQ). A meta-analysis aims to clarify inconsistent findings on how FADS2 influences the breastfeeding-IQ association.
Area of Science:
- Genetics
- Nutrition Science
- Developmental Psychology
Background:
- Breastfeeding is linked to higher IQ, potentially due to long-chain polyunsaturated fatty acids in breast milk.
- Gene-breastfeeding interactions involving FADS2 variants and intelligence have been observed, but findings are inconsistent.
Purpose of the Study:
- To clarify the interaction between FADS2 gene variants and breastfeeding in their association with IQ.
- To conduct a consortium-based meta-analysis of independent studies using harmonized data and standardized analysis scripts.
Main Methods:
- Meta-analysis of independent studies with harmonized data and standardized analysis scripts.
- Inclusion criteria: studies with data on breastfeeding, IQ, FADS2 polymorphisms (rs174575 or rs1535), and European ancestry.
Main Results:
- N/A - Protocol for a meta-analysis.
Conclusions:
- This meta-analysis aims to improve understanding of the FADS2-breastfeeding interaction and its biological insights.
- Replicating earlier studies, conducting additional analyses, and evaluating heterogeneity will enhance knowledge on long-chain polyunsaturated fatty acids' role in the breastfeeding-IQ association.
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