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Cell-specific biomarkers and targeted biopharmaceuticals for breast cancer treatment
Mei Liu1, Zhiyang Li1,2, Jingjing Yang3
1School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Abstract:
Breast cancer is the second leading cause of cancer death among women, and its related treatment has been attracting significant attention over the past decades. Among the various treatments, targeted therapy has shown great promise as a precision treatment, by binding to cancer cell-specific biomarkers. So far, great achievements have been made in targeted therapy of breast cancer. In this review, we first discuss cell-specific biomarkers, which are not only useful for classification of breast cancer subtyping but also can be utilized as goals for targeted therapy. Then, the innovative and generic-targeted biopharmaceuticals for breast cancer, including monoclonal antibodies, non-antibody proteins and small molecule drugs, are reviewed. Finally, we provide our outlook on future developments of biopharmaceuticals, and provide solutions to problems in this field.
Insights
Targeted therapy offers promising precision treatment for breast cancer by targeting specific biomarkers. This review covers biomarkers, targeted biopharmaceuticals, and future directions for breast cancer treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Breast cancer remains a significant cause of mortality in women.
- Targeted therapy has emerged as a key precision treatment strategy.
- Biomarker identification is crucial for effective breast cancer treatment.
Purpose of the Study:
- To review cell-specific biomarkers for breast cancer classification and targeted therapy.
- To discuss innovative and generic targeted biopharmaceuticals for breast cancer.
- To provide an outlook on future developments and solutions in breast cancer biopharmaceuticals.
Main Methods:
- Literature review of targeted therapy in breast cancer.
- Analysis of cell-specific biomarkers and their role in treatment.
- Categorization of biopharmaceuticals including monoclonal antibodies, proteins, and small molecules.
Main Results:
- Cell-specific biomarkers are vital for breast cancer subtyping and therapeutic targeting.
- Various targeted biopharmaceuticals, including antibodies and small molecules, have shown efficacy.
- Significant advancements have been made in the targeted therapy of breast cancer.
Conclusions:
- Targeted therapy, guided by specific biomarkers, represents a major advancement in breast cancer treatment.
- Future developments in biopharmaceuticals hold promise for improved patient outcomes.
- Addressing current challenges is essential for the continued progress of breast cancer biopharmaceutical therapies.
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