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Genes for a 'Wellderly' Life.
John S K Kauwe1, Alison Goate2
1Department of Biology, Brigham Young University, Provo, UT 84602, USA.
Trends in Molecular Medicine
|June 18, 2016
Summary
Genetic protective variants for Alzheimer's disease and coronary artery disease may contribute to a long, healthy life. This research explores the link between these genetic factors and successful aging, going beyond traditional longevity genes.
Area of Science:
- Genetics
- Gerontology
- Neuroscience
Background:
- A long and healthy life is a universal aspiration.
- Genetic factors alone do not fully account for healthy aging.
- Emerging research indicates a connection between genetic predispositions and healthy aging outcomes.
Purpose of the Study:
- To investigate the role of protective genetic variants in Alzheimer's disease (AD) and coronary artery disease (CAD) in promoting healthy aging.
- To explore the contribution of AD and CAD genetic resilience to overall longevity and well-being.
Main Methods:
- Analysis of genetic data related to longevity.
- Review of recent research on genetic variants impacting AD and CAD.
- Correlation studies between protective genetic profiles and healthy aging indicators.
Main Results:
- Protective genetic variants for Alzheimer's disease (AD) are associated with healthy aging.
- Genetic resilience factors for coronary artery disease (CAD) also appear to contribute to longevity.
- These genetic factors offer a partial explanation for healthy aging beyond known longevity genes.
Conclusions:
- Genetic variants conferring protection against Alzheimer's disease and coronary artery disease play a role in achieving a long and healthy life.
- Understanding these genetic underpinnings can advance strategies for promoting healthy aging.
- Future research should further elucidate the mechanisms by which these protective variants influence aging processes.
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