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Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

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Chronic Kidney Disease I: Introduction01:25

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Nephrotic Syndrome II : Assessment and Medical Management01:26

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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Related Experiment Video

Updated: Mar 19, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Silent diabetic nephropathy.

Samar M Said1, Samih H Nasr1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Kidney International
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy often shows kidney damage before moderately increased albuminuria appears. This suggests albuminuria is not a sensitive early marker, highlighting the need for new biomarkers to detect diabetic kidney disease sooner.

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Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
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Area of Science:

  • Nephrology
  • Diabetology
  • Pathology

Background:

  • Moderately increased albuminuria is traditionally considered the initial clinical indicator of diabetic nephropathy.
  • However, existing morphometric and autopsy studies reveal significant glomerular and tubulointerstitial damage can occur before albuminuria is detectable.

Purpose of the Study:

  • To underscore the limitations of albuminuria as an early diagnostic marker for diabetic nephropathy.
  • To emphasize the critical need for identifying more sensitive biomarkers for early-stage diabetic kidney disease.

Main Methods:

  • Review of previous morphometric studies on diabetic kidney pathology.
  • Analysis of autopsy findings in diabetic patients, specifically examining kidney structure.
  • Comparative assessment of albuminuria levels against observed kidney damage.

Main Results:

  • Morphometric and autopsy data indicate substantial kidney damage precedes the onset of moderately increased albuminuria in some diabetic individuals.
  • This demonstrates that albuminuria is not a sufficiently sensitive marker for detecting early-stage diabetic nephropathy.

Conclusions:

  • Current evidence suggests moderately increased albuminuria is a late indicator of diabetic nephropathy.
  • There is an urgent requirement for novel biomarkers that can detect diabetic kidney disease at its earliest stages, allowing for timely intervention.