Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Epigenetic Regulation01:37

Epigenetic Regulation

4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.1K
Epigenetic Regulation01:46

Epigenetic Regulation

26.2K
26.2K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.8K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.8K
Epistasis01:39

Epistasis

51.1K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
51.1K
Histone Modification02:32

Histone Modification

16.9K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Recurrent and Non-Recurrent Copy Number Variants in Native Americans and a Cosmopolitan Sample in Relation to Alcohol Use Disorder and Other Psychiatric Diseases.

Molecular neurobiology·2026
Same author

Associations between childhood trauma and amygdala- and insula-centered resting-state functional connectivity in alcohol use disorder.

Journal of psychiatric research·2026
Same author

Genetic regulation of AIF1 shapes immune and liver injury profiles in chronic alcohol use.

JCI insight·2026
Same author

From Gut to Globe: Endogenous Endophthalmitis as a Sentinel Sign of Polymicrobial Intra-Abdominal Infection.

Clinical case reports·2026
Same author

Recurrent & non-recurrent copy number variants in Native Americans and a cosmopolitan sample in relation to Alcohol Use Disorder and other psychiatric diseases.

Research square·2026

Related Experiment Video

Updated: Mar 19, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

Making Sense of Epigenetics.

Kornel Schuebel1, Miri Gitik1, Katharina Domschke1

  • 1Laboratory of Neurogenetics and Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland (Drs Schuebel, Gitik, and Goldman); Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany (Dr Domschke).

The International Journal of Neuropsychopharmacology
|June 18, 2016
PubMed
Summary

Epigenetics, including DNA methylation, offers potential psychiatric disorder treatments. Distinguishing causal epigenetic changes from life experience effects remains a key challenge for future research.

Keywords:
DNA methylationchromatinepigeneticsneuropsychiatric disorders

More Related Videos

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.3K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K

Related Experiment Videos

Last Updated: Mar 19, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.3K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Gene-environment interactions in psychiatric disorders are not well understood.
  • Genetic approaches have not yielded new psychiatric treatments due to disorder heterogeneity and unknown mechanisms.
  • Epigenetic mechanisms like DNA methylation and chromatin structure changes are implicated in psychiatric disorders.

Purpose of the Study:

  • To define epigenetics and explore its relevance to psychiatric disease.
  • To discuss epigenetic mechanisms contributing to psychiatric illness.
  • To speculate on future research directions in psychiatric epigenetics.

Main Methods:

  • Literature review and synthesis of current research on epigenetics and psychiatric disorders.
  • Exploration of epigenetic mechanisms, including DNA methylation and chromatin remodeling.
  • Discussion of challenges in establishing causality between epigenetic changes and disease.

Main Results:

  • Epigenetic modifications are increasingly recognized as potential contributors to psychiatric disorders.
  • The reversible nature of epigenetic changes suggests novel therapeutic avenues.
  • A significant challenge is differentiating disease-causal epigenetic alterations from those resulting from life experiences.

Conclusions:

  • Epigenetics provides a promising framework for understanding and potentially treating psychiatric illnesses.
  • Further research is needed to clarify causal relationships and develop targeted epigenetic therapies.
  • Addressing the heterogeneity of psychiatric disorders requires a deeper understanding of epigenetic mechanisms.