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Let thy left brain know what thy right brain doeth: Inter-hemispheric compensation of functional deficits after brain
Paolo Bartolomeo1, Michel Thiebaut de Schotten2
1INSERM U1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et Marie Curie-Paris 6, UMRS 1127, Institut du Cerveau et de la Moelle épinière (ICM), F-75013 Paris, France; AP-HP, Department of Neurology, IFR 70, Salpêtrière Hospital, Paris, France.
Abstract:
Recent evidence revealed the importance of inter-hemispheric communication for the compensation of functional deficits after brain damage. This review summarises the biological consequences observed using histology as well as the longitudinal findings measured with magnetic resonance imaging methods in brain damaged animals and patients. In particular, we discuss the impact of post-stroke brain hyperactivity on functional recovery in relation to time. The reviewed evidence also suggests that the proportion of the preserved functional network both in the lesioned and in the intact hemispheres, rather than the simple lesion location, determines the extent of functional recovery. Hence, future research exploring longitudinal changes in patients with brain damage may unveil potential biomarkers underlying functional recovery.
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