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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

310
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
310
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

324
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
324
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

305
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
305
Aging01:26

Aging

966
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
966
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

344
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
344
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310

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Updated: Mar 19, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Geriatrics: Year in review.

Holly M Holmes1, Maureen S Beck1, Julie H Rowe2

  • 1Division of Geriatric and Palliative Medicine, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.

Journal of Geriatric Oncology
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Geriatric oncology updates cover hypertension, dementia, vaccination, and frailty. New research supports aggressive blood pressure targets, dementia screening, updated vaccines, and interventions for frailty syndrome.

Keywords:
DementiaFrailtyGeriatric oncologyGeriatricsHypertensionImmunization

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Area of Science:

  • Geriatric Medicine
  • Geriatric Oncology

Background:

  • General geriatrics knowledge is crucial for geriatric oncology.
  • Updates in key geriatric areas inform cancer care for older adults.

Purpose of the Study:

  • To review recent advancements in general geriatrics relevant to geriatric oncology.
  • To provide updates on hypertension, dementia, vaccination, and frailty.

Main Methods:

  • Review of high-impact geriatrics journals from the past two years.
  • Analysis of journals publishing geriatric updates.

Main Results:

  • Hypertension: Lower, aggressive blood pressure targets are supported, though cognitive effects are debated.
  • Dementia: Screening tools are recommended; lifestyle interventions show promise.
  • Vaccination: New recommendations for pneumococcal and zoster vaccines.
  • Frailty: Interventions involving exercise, nutrition, and pharmacologic treatments show potential.

Conclusions:

  • Recent geriatric research offers evolving strategies for managing common conditions in older adults.
  • These updates are pertinent for optimizing care within geriatric oncology settings.