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Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions
Abraham Morgentaler1, Michael Zitzmann2, Abdulmaged M Traish3
1Men's Health Boston and Harvard Medical School, Boston, MA.
Mayo Clinic Proceedings
|June 18, 2016
Summary
Testosterone deficiency (TD) is a significant medical condition affecting men
Area of Science:
- Endocrinology
- Urology
- Men's Health
Background:
- Testosterone deficiency (TD), also known as male hypogonadism, is a growing concern.
- Existing treatments for TD face widespread scrutiny and debate.
- International experts convened to establish consensus on TD and its management.
Purpose of the Study:
- To establish an expert consensus on the diagnosis and treatment of testosterone deficiency (TD).
- To address concerns regarding testosterone (T) therapy and its associated risks.
- To provide evidence-based recommendations for T therapy in men with TD.
Main Methods:
- An international expert consensus conference was held on October 1, 2015, in Prague, Czech Republic.
- Experts from urology, endocrinology, diabetology, internal medicine, and basic science participated.
- Nine resolutions regarding TD and T therapy were debated and unanimously approved.
Main Results:
- Testosterone deficiency (TD) is a clinically significant condition impacting male sexuality, reproduction, general health, and quality of life.
- Testosterone (T) therapy is effective, rational, and evidence-based for men with TD.
- Evidence does not support increased risks of cardiovascular events or prostate cancer with T therapy.
- No reliable T concentration threshold exists to predict treatment response.
- No age-specific restrictions against T therapy in men are scientifically supported.
Conclusions:
- Testosterone deficiency (TD) is a global public health concern requiring evidence-based management.
- Testosterone (T) therapy is a safe and effective treatment for men with TD.
- Further research is warranted to explore T therapy's benefits for cardiometabolic diseases like diabetes.
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