Influence of ibuprofen on renal function in acutely endotoxemic dogs

Dogs were anesthetized with pentobarbital and instrumented to measure renal function. An inulin infusion was started; after an appropriate equilibration period one group was infused with endotoxin only (ETOX), a second group was pretreated with ibuprofen before (PRET) endotoxin, and a third group was post-treated with ibuprofen after (POST) endotoxin. Renal blood flow decreased in all animals, but renal vascular resistance increased only in the POST group animals. Urine flow and osmolar clearance decreased and free water clearance increased in the post-treated animals. Glomerular filtration rate as well as electrolyte excretion decreased in both the ETOX and POST group animals. Renal glucose output was unchanged in the ETOX and POST groups, but in the ibuprofen-pretreated animals there was significant net uptake, indicating increased utilization. Ibuprofen alone had no significant effect on blood flow, renal resistance, filtration rate, or solute and water handling. However, when ibuprofen was given 30 min after the induction of endotoxemia, the changes brought about by endotoxin alone were further intensified.