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Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies

Kevon Parmesar1, Kavita Raj2

  • 1Department of Haematology, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK; Kings College London, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.

Advances in Hematology
|June 18, 2016
PubMed

Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis. This review is an overview of these strategies and contemporaneous outcomes for hematological malignancies in adult haploidentical stem cell transplant recipients.

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