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DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers

Nicole Schupp1, Helga Stopper2, August Heidland3

  • 1Institute of Toxicology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany.

Oxidative Medicine and Cellular Longevity
|June 18, 2016
PubMed

Insights

Patients with chronic kidney disease (CKD) have higher cancer risks. This review assesses DNA damage biomarkers in lymphocytes to estimate cancer risk and monitor treatment effectiveness in CKD patients.

Area of Science:

  • Nephrology
  • Genetics
  • Oncology

Background:

  • Patients with chronic kidney disease (CKD) face elevated cancer risks compared to healthy individuals.
  • Understanding genomic damage in CKD is crucial for cancer risk assessment and evaluating therapeutic interventions.
  • Previous studies indicate chromosomal abnormalities, impaired DNA repair, and DNA lesions in CKD patients.

Purpose of the Study:

  • To review and evaluate common methods for quantifying DNA damage in peripheral blood lymphocytes of CKD patients.
  • To assess the feasibility of these methods for routine clinical analysis.
  • To determine the potential of these DNA damage markers in predicting clinical outcomes for CKD patients.

Main Methods:

  • Evaluation of the cytokinesis-block micronucleus assay for chromosomal aberrations.
  • Assessment of the comet assay for structural DNA lesions.
  • Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine quantification for oxidatively modified DNA bases.

Main Results:

  • The review examines the practicality and predictive value of three key biomarkers for DNA damage.
  • These biomarkers are measurable in easily accessible peripheral blood lymphocytes.
  • The focus is on their utility in estimating cancer risk and monitoring treatment impact in CKD.

Conclusions:

  • Accessible biomarkers in lymphocytes can quantify genomic damage in CKD patients.
  • These markers hold potential for predicting cancer risk and treatment response.
  • Further evaluation is needed to establish their clinical utility in managing CKD patients.

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