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Updated: Mar 19, 2026
Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
Danny L Costantini1, Reza Vali1, Susan McQuattie2
1Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Abstract:
We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.
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