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Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates Causing Invasive and

Si Hyun Kim1, Il Kwon Bae2, Dongchul Park1

  • 1Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.

Biomed Research International
|June 18, 2016
PubMed

Insights

This study tracked Streptococcus pneumoniae serotypes and antibiotic resistance in Korea from 2008-2014. Key findings show shifts in common serotypes and increased multidrug resistance, highlighting the need for ongoing surveillance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Streptococcus pneumoniae causes significant global morbidity and mortality.
  • Understanding pneumococcal serotype distribution and antimicrobial resistance is crucial for public health interventions.

Purpose of the Study:

  • To evaluate the distribution of common Streptococcus pneumoniae serotypes in Korea.
  • To assess the antimicrobial susceptibility patterns of S. pneumoniae isolates.
  • To analyze changes in serotype prevalence and resistance over a seven-year period.

Main Methods:

  • Analysis of 378 invasive and noninvasive S. pneumoniae isolates collected between 2008 and 2014.
  • Serotyping and antimicrobial susceptibility testing were performed on all isolates.
  • Vaccine coverage rates for PCV7, PCV10, PCV13, and PPSV23 were calculated.

Main Results:

  • Common serotypes/serogroups included 3, 35, 19A, 19F, 6A, and 34.
  • Vaccine coverage varied, with PPSV23 showing the highest rate (62.4%).
  • A decrease in serotypes 19A and 19F was observed, alongside an increase in non-vaccine serotypes.
  • Multidrug resistance (MDR) was prevalent in 34.7% of isolates, with serotypes 19A and 19F predominant.
  • A significant increase in levofloxacin resistance (7.2%) was noted.

Conclusions:

  • Significant shifts in pneumococcal serotype distribution and antimicrobial susceptibility occurred in Korea following the introduction of pneumococcal vaccines.
  • Continuous monitoring of pneumococcal serotypes and their antibiotic susceptibilities is essential for effective disease control and prevention strategies.

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