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Microstructural maturation of white matter tracts in encephalopathic neonates
Akash P Kansagra1, Marc C Mabray2, Donna M Ferriero3
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus Box 8131, Saint Louis, MO 63110.
Purpose:
This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development.
Methods:
NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy.
Results:
Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome.
Conclusion:
NODDI may allow more detailed characterization of microstructural maturation than FA.
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