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Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
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Nutrition in burn injury: any recent changes?
Mette M Berger1, Olivier Pantet
1Service of Adult Intensive Care Medicine and Burns, CHUV University Hospital, Lausanne, Switzerland.
Current Opinion in Critical Care
|June 18, 2016
Summary
Recent burn research focuses on metabolic response modulation. Intracellular mitochondrial changes drive hypermetabolism, but pharmacological interventions and enteral nutrition show clinical benefits, though glucose control in children needs more study.
Area of Science:
- Biochemistry
- Metabolism
- Critical Care Medicine
Background:
- Burn resuscitation advanced in the 1980s.
- Current research targets metabolic response modulation and substrate utilization optimization.
- Clinical practice variability hinders burn center comparisons.
Purpose of the Study:
- To review recent findings on burn-induced metabolic turmoil.
- To explore intracellular mechanisms and long-term metabolic alterations.
- To assess the efficacy of pharmacological and nutritional interventions.
Main Methods:
- Review of recent scientific literature on burn metabolism.
- Analysis of intracellular mechanisms, including mitochondrial function.
- Evaluation of pharmacological agents (insulin, propranolol, oxandrolone) and enteral feeding.
Main Results:
- Early mitochondrial alterations contribute to hypermetabolism.
- Elevated protein and glucose turnover are long-lasting metabolic changes.
- Pharmacological modulation and enteral nutrition offer clinical benefits, but glucose control in children requires caution.
Conclusions:
- Burn patients exhibit unique, prolonged inflammatory and metabolic responses.
- Understanding intracellular mechanisms is key to managing burn hypermetabolism.
- Optimizing substrate utilization and nutritional support are crucial for recovery.
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