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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Long Noncoding RNA: Recent Updates in Atherosclerosis.

Hao Li1, Hongming Zhu2, Junbo Ge3

  • 11. Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

International Journal of Biological Sciences
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are key epigenetic regulators implicated in atherosclerosis. This review explores their roles in disease development and potential as therapeutic targets.

Keywords:
AtherosclerosisGene regulationLong noncoding RNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides with significant epigenetic regulatory functions.
  • Dysregulation of lncRNAs is observed in numerous pathological conditions, affecting diverse biological processes.
  • Emerging evidence links lncRNAs to the regulation of key cellular components and processes in atherosclerosis, including smooth muscle cells, endothelial cells, macrophages, and lipid metabolism.

Purpose of the Study:

  • To review and synthesize recent findings on the involvement of lncRNAs in the development of atherosclerosis (atherogenesis).
  • To discuss the potential of lncRNAs as novel therapeutic targets for atherosclerosis.

Main Methods:

  • Literature review of recent studies on lncRNAs and atherosclerosis.
  • Analysis of lncRNA functions in cellular and molecular pathways relevant to atherogenesis.

Main Results:

  • lncRNAs play multifaceted roles in regulating cellular and molecular events during atherogenesis.
  • Specific lncRNAs are implicated in the dysfunction of vascular cells and altered lipid metabolism, contributing to atherosclerosis progression.

Conclusions:

  • lncRNAs represent a critical class of molecules involved in the pathogenesis of atherosclerosis.
  • Targeting lncRNAs offers promising therapeutic strategies for managing and treating atherosclerosis.