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High-dose methylprednisolone for remission induction in children with acute nonlymphoblastic leukemia
G Hiçsönmez1, S Ozsoylu, A Gürgey
1Department of Pediatrics, Hacettepe University Faculty of Medicine, Hacettepe Children's Hospital, Ankara, Turkey.
European Journal of Haematology
|May 1, 1989
Abstract:
The effectiveness of high-dose intravenous methylprednisolone (HIVMP) in inducing an initial remission was examined in a child with acute nonlymphoblastic leukemia (ANLL). Dramatic clinical and hematological improvement with 7% marrow blasts was obtained in 3 weeks with HIVMP treatment without giving any other antileukemic drugs. Based on the results of this preliminary observation we suggest that high-dose methylprednisolone (20-30 mg/kg) might be a useful approach when applied as an initial short treatment in childhood ANLL.