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Development of neural inducing capacity in dissociated Xenopus embryos
1Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Developmental Biology
|July 1, 1989
Abstract:
During gastrulation in amphibians, dorsal ectoderm is converted by induction from an epidermal pathway to central nervous system (CNS). We show in this report that the ability of the embryo to manufacture this neural inducing signal is not dependent upon intercellular communication between early cleavage and early gastrula stages. This result is consistent with the interpretation that the cell lineage that induces CNS formation arises itself by a cell-autonomous mechanism, perhaps specified by materials inherited from the fertilized egg.