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Assessment of severity of leukoaraiosis: a diffusional kurtosis imaging study
Shuhui Xu1, Deqiu Ye1, Tao Lian1
1Department of Radiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
Objective:
The objective was to investigate the capabilities of diffusional kurtosis imaging (DKI) in detection of age-related white matter (WM) changes in elderly patients with leukoaraiosis.
Material And Methods:
Fractional anisotropy (FA), kurtosis, and diffusion parameters in the frontal lobe and parietal lobe were compared between 14 patients at Fazekas scale 0 and 1, and 15 patients at Fazekas scale 2 and 3.
Results:
FA and DKI parameters were significantly altered in the ischemic lesions vs normal regions of WM in the severe patients.
Conclusion:
DKI can provide sensitive imaging biomarkers for assessing the severity of leukoaraiosis in reference to Fazekas score.
