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Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
Published on: July 16, 2018
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Technical principles in glioma surgery and preoperative considerations
Daria Krivosheya1,2, Sujit S Prabhu3, Jeffrey S Weinberg1
1Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Room FC7.2000, Unit 442, Houston, TX, 77030, USA.
Journal of Neuro-Oncology
|June 19, 2016
Summary
Maximizing safe glioma resection involves preoperative imaging and intraoperative techniques. These methods define tumor extent and map brain function to improve surgical outcomes and minimize deficits.
Area of Science:
- Neurosurgery
- Oncology
- Medical Imaging
Background:
- Gliomas are intrinsic brain tumors lacking clear surgical margins.
- Resection is challenging due to infiltration of eloquent brain areas.
- Maximal safe resection is the primary surgical goal.
Purpose of the Study:
- To review preoperative investigations for glioma characterization.
- To outline intraoperative adjuncts for maximal safe resection.
- To discuss functional mapping and monitoring principles.
Main Methods:
- Review of preoperative imaging modalities (e.g., MRI, PET).
- Discussion of intraoperative tools (e.g., fluorescence, navigation).
- Explanation of cortical and subcortical mapping techniques.
Main Results:
- Preoperative studies define tumor extent and feasibility of resection.
- Intraoperative adjuncts identify infiltrated tissues for maximal resection.
- Functional mapping minimizes postoperative neurological deficits.
Conclusions:
- Combined preoperative and intraoperative strategies are crucial.
- These integrated approaches optimize glioma resection and patient outcomes.
- Minimizing neurological deficits is a key consideration.
