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Updated: Jul 12, 2026

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis

Published on: February 19, 2013

Chronic colitis after Aeromonas infection.

J M Willoughby¹, A F Rahman, M M Gregory

¹Department of Medicine, Lister Hospital, Stevenage, Hertfordshire.

|May 1, 1989

Summary

This summary is machine-generated.

Bacterial infections with Aeromonas species may lead to chronic colitis, including ulcerative colitis. Further research is needed to confirm if acute bacterial colitis can trigger long-term inflammatory bowel disease.

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Published on: September 22, 2019

Area of Science:

Gastroenterology
Infectious Diseases
Pathology

Background:

Acute colitis can be caused by various pathogens.
The long-term sequelae of certain bacterial infections in the colon are not fully understood.
Aeromonas hydrophila and Aeromonas sobria are known bacterial pathogens.

Observation:

Three patients developed chronic colitis following acute infections with Aeromonas hydrophila or Aeromonas sobria.
Infection resolution did not prevent progression to chronic ulcerative colitis in these cases.

Findings:

Acute bacterial colitis, specifically by Aeromonas species, may precede the development of chronic ulcerative colitis.
Two patients responded to anti-inflammatory drugs, while one required surgery (panproctocolectomy).

Implications:

Bacterial infections could be a contributing factor in the pathogenesis of chronic colitis.
Prospective multicenter trials are recommended to validate the hypothesis linking acute infective colitis to chronic disease development.