Evidence for a relationship between high fibrinogen levels and decreased thrombin activity in vivo in elderly

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Published on: April 1, 2015

F Marongiu1, A M Mamusa, P Dessalvi

  • 1Institute of Internal Medicine, University of Cagliari, Italy.

Haemostasis
|January 1, 1989
PubMed

In order to investigate whether high fibrinogen levels were associated with elevated thrombin activity, we measured fibrinogen and fibrinopeptide A in 37 elderly healthy subjects ranging from 60 to 93 years. Fibrinogen levels (519.1 +/- 127.0 mg/dl) and fibrinopeptide A (5.9, 0.9-18.1 ng/ml) were significantly higher than in younger controls. A highly significant negative linear correlation was found between fibrinogen and fibrinopeptide A in the elderly subjects (p less than 0.01). However, a polynomial regression showed that this negative relationship was present at the fibrinogen levels ranging between 420 and 700 mg/dl. Our results suggest that high fibrinogen levels in elderly subjects do not necessarily mean that their thrombin activity is concomitantly increased.

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